ea0022p592 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010
Garcia-Galiano David
, Navarro Victor M
, Roa Juan
, Ruiz-Pino Francisco
, Castellano Juan M
, Dieguez Carlos
, Pinilla Leonor
, Tena-Sempere Manuel
The hypothalamic peptide, nesfatin-1, derived from the precursor NEFA/nucleobindin2 (NUCB2), was recently identified as central anorexigenic molecule, acting in a leptin-independent manner. Yet, its potential involvement in the regulation of other biological functions gated by body energy status remains unexplored. We show herein that NUCB2/nesfatin-1 is involved in the control of female puberty. NUCB2/nesfatin mRNA and protein were detected at the hypothalamus of pubertal fem...